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Gaucher disease is caused due to deficiency of ______________

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Gaucher disease is caused due to deficiency of ______________

(a) hexosaminidase A

(b) lysosomes

(c) glucocerebrosidase

(d) mannose phophate

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The question is from Cytoplasmic Membrane Systems topic in section Cytoplasmic Membrane Systems of Cell Biology

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The correct choice is (c) glucocerebrosidase

The explanation is: Gaucher’s disease is caused by the deficiency of the lysosomal enzyme glucocerebrosidase. Due to this deficiency, large quantities of glucocerebroside accumulate in the lysosomes of macrophages.

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