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The last step in structure classification involves grouping proteins/domains of similar structures.

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The last step in structure classification involves grouping proteins/domains of similar structures.

(a) True

(b) False

This question was addressed to me during an interview for a job.

My query is from Protein Structure Classification in division Structural Bioinformatics of Bioinformatics

1 Answer

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Correct option is (a) True

Explanation: Once multidomain proteins are split into separate domains, structure comparison can be conducted at the domain level, either through manual inspection, or automated structural alignment, or a combination of both. This step involves grouping proteins/domains of similar structures and clustering them based on different levels of resemblance in secondary structure composition and arrangement of the secondary structures in space.

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