Question

In dot matrix in ab initio methods, the diagonals _____________ to the main diagonal represent regions that can self hybridize.

(a) parallel

(b) cutting in random fashion

(c) perpendicular

(d) adjacent parallel

I got this question during a job interview.

I need to ask this question from Ab Initio Approach topic in chapter RNA Structure Prediction of Bioinformatics

Answer 1

Correct option is (c) perpendicular

Easiest explanation: The diagonals perpendicular to the main diagonal represent regions that can self hybridize to form double-stranded structure with traditional A–U and G–C base pairs. In reality, the pattern detection in a dot matrix is often obscured by high noise levels.