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The intramolecular approach does not depend on sequence similarity between the proteins to be compared.

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The intramolecular approach does not depend on sequence similarity between the proteins to be compared.

(a) True

(b) False

This question was addressed to me in an internship interview.

This interesting question is from Protein Structure Comparison topic in portion Structural Bioinformatics of Bioinformatics

1 Answer

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Correct answer is (a) True

The explanation: The intramolecular approach relies on structural internal statistics and therefore does not depend on sequence similarity between the proteins to be compared. In addition, this method does not generate a physical superposition of structures but instead provides a quantitative evaluation of the structural similarity between corresponding residue pairs.

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