Question

VAST is a web server that performs alignment using intramolecular approaches only.

(a) True

(b) False

This question was posed to me in an interview for job.

I would like to ask this question from Protein Structure Comparison topic in section Structural Bioinformatics of Bioinformatics

Answer 1

Right option is (b) False

The explanation is: VAST (Vector Alignment Search Tool) is a web server that performs alignment using both the inter- and intramolecular approaches. The superposition is based on information of directionality of secondary structural elements (represented as vectors). Optimal alignment  between two structures is defined by the highest degree of vector matches.