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In CATH, Structural domain separation is carried by ___________

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In CATH, Structural domain separation is carried by ___________

(a) manual comparison only

(b) computer programs only

(c) human expertise only

(d) a combined effort of a human expert and computer programs

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Question is from Protein Structure Classification topic in portion Structural Bioinformatics of Bioinformatics

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Correct choice is (d) a combined effort of a human expert and computer programs

Explanation: CATH classifies proteins based on the automatic structural alignment program SSAP as well as manual comparison. Structural domain separation is carried out also as a combined effort of a human expert and computer programs. Individual domain structures are classified at five major levels: class, architecture, fold/topology, homologous superfamily, and homologous family.

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