Question

The predefined alignment requiring method also depends on the quality of the input alignment. If there ___ errors in the alignment, covariation signals ____ detected.

(a) are, will be

(b) are, will not be

(c) are not, will not be

(d) are not, possibly will not be

The question was asked in an interview for internship.

This key question is from Comparative Approach topic in portion RNA Structure Prediction of Bioinformatics

Answer 1

Correct option is (b) are, will not be

The best explanation: The selection of one single consensus structure is also a drawback because alternative and evolutionarily unconserved structures are not predicted. The RNAalifold is an example of this type of program based on predefined aligned sequences.