Question

The first step in structure classification is to remove redundancy from databases.

(a) True

(b) False

I had been asked this question during an interview.

This interesting question is from Protein Structure Classification topic in section Structural Bioinformatics of Bioinformatics

Answer 1

Correct choice is (a) True

To explain I would say: Among the tens of thousands of entries in PDB, the majority of the structures are redundant as they correspond to structures solved at different resolutions, or associated with different ligands or with single-residue mutations. The redundancy can be removed by selecting representatives through a sequence alignment–based approach.