Question

Which of the following is untrue regarding the Progressive Alignment Method?

(a) Progressive alignment depends on the stepwise assembly of multiple alignments and is heuristic in nature

(b) It speeds up the alignment of multiple sequences through a multistep process

(c) It first conducts pair wise alignments for each possible pair of sequences using the Needleman–Wunsch global alignment method and records these similarity scores from the pair wise comparisons

(d) Its drawback is it slows down the alignment of multiple sequences through a single step process

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I'm obligated to ask this question of Heuristic Algorithms topic in portion Multiple Sequence Alignment of Bioinformatics

Answer 1

The correct option is (d) Its drawback is it slows down the alignment of multiple sequences through a single step process

Explanation: Progressive alignment speeds up the alignment of multiple sequences through a multistep process further, the scores can either be percent identity or similarity scores based on a particular substitution matrix. Both scores correlate with the evolutionary distances between sequences.