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In FASTA, For a Z-score > 15, the match can be considered extremely ______ with _____ of a homologous relationship.

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In FASTA, For a Z-score > 15, the match can be considered extremely ______ with _____ of a homologous relationship.

(a) insignificant, uncertainty

(b) significant, uncertainty

(c) significant, certainty

(d) insignificant, certainty

I got this question during an internship interview.

The above asked question is from Comparison of FASTA and BLAST in division Database Similarity Searching of Bioinformatics

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The correct answer is (c) significant, certainty

To elaborate: If Z is in the range of 5 to 15, the sequence pair can be described as highly probable homologs. If Z<5, their relationship is described as less certain.

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