Question

The dynamic programming method produces ____ structure with _____ score.

(a) one, single best

(b) multiple, single best

(c) multiple, multiple

(d) single, multiple

I had been asked this question during an interview.

My question comes from Ab Initio Approach in chapter RNA Structure Prediction of Bioinformatics

Answer 1

Right answer is (a) one, single best

Explanation: However, this is potentially a drawback of this approach. In reality an RNA may exist in multiple alternative forms with near minimum energy but not necessarily the one with maximum base pairs.