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Like Mfold, RNAfold only examines the energy terms of the optimal alignment in a dot plot.

Like Mfold, RNAfold only examines the energy terms of the optimal alignment in a dot plot.

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asked Sep 12, 2021 in Bioinformatics by nolan (111k points)

Like Mfold, RNAfold only examines the energy terms of the optimal alignment in a dot plot.

(a) True

(b) False

The question was posed to me in final exam.

This intriguing question comes from Ab Initio Approach in chapter RNA Structure Prediction of Bioinformatics

bioinformatics
rna structure prediction
ab initio approach

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1 Answer

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answered Sep 13, 2021 by myra (687k points)
selected Sep 13, 2021 by nolan

Best answer

Right option is (b) False

The best I can explain: It is one of the web programs in the Vienna package. Unlike Mfold, which only examines the energy terms of the optimal alignment in a dot plot, RNAfold extends the sequence alignment to the vicinity of the optimal diagonals to calculate thermodynamic stability of alternative structures.

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