Question

Which of the following is untrue about GeneMark?

(a) It is a suite of gene prediction programs based on the fifth-order HMMs

(b) The main program is trained on a number of complete microbial genomes

(c) A GeneMark heuristic program can be used to improve accuracy

(d) If the sequence to be predicted is from a non-listed organism, the most closely related organism can be chosen as the basis for computation

I had been asked this question in semester exam.

My query is from Categories of Gene Prediction Programs topic in portion Gene and Promoter Prediction of Bioinformatics

Answer 1

Right choice is (c) A GeneMark heuristic program can be used to improve accuracy

Best explanation: Another option for predicting genes from a new organism is to use a self-trained program GeneMarkS as long as the user can provide at least 100 kbp of sequence on which to train the model. If the query sequence is shorter than 100 kbp, a GeneMark heuristic program can be used with some loss of accuracy. In addition to predicting prokaryotic genes, GeneMark also has a variant for eukaryotic gene prediction using HMM.