Question

The homology-based method makes predictions based on significant matches of the query sequence with sequences of known genes.

(a) True

(b) False

The question was asked in an online quiz.

This question is from Categories of Gene Prediction Programs in chapter Gene and Promoter Prediction of Bioinformatics

Answer 1

Correct choice is (a) True

The best I can explain: For instance, if a translated DNA sequence is found to be similar to a known protein or protein family from a database search, this can be strong evidence that the region codes for a protein. Alternatively, when possible exons of a genomic DNA region match a sequenced cDNA, this also provides experimental evidence for the existence of a coding region.