Question

A caveat of phylogenetic footprinting is to extract noncoding sequences Upstream of corresponding genes and focus the comparison to this region only, which helps to prevent false positives.

(a) True

(b) False

I had been asked this question by my school teacher while I was bunking the class.

I would like to ask this question from Prediction Algorithms in section Promoter and Regulatory Element Prediction of Bioinformatics

Answer 1

The correct choice is (a) True

For explanation I would say: The predictive value of this method also depends on the quality of the subsequent sequence alignments. Advanced alignment programs can be used. Even more sophisticated expectation maximization (EM) and Gibbs sampling algorithms can be used in detecting weakly conserved motifs.