Question

In Stochastic search methods, they include methods such as Monte Carlo simulation, simulated annealing, Tabu search, genetic algorithms and evolutionary programming.

(a) True

(b) False

I got this question in an interview.

Enquiry is from Conformational Flexibility topic in section Predicting the Structure of Protein – Biomolecular Interactions of Bioinformatics

Answer 1

Correct choice is (a) True

The best explanation: Stochastic processes use a random sampling procedure to search conformational space. The ligand molecule performs a random walk in space in the receptor cavity. Usually, the ligand is placed in a random orientation in the receptor cavity. Then at each step a small displacement is made in any of the degrees of freedom of the ligand molecule (translation, rotation or torsion angle).