Question

Domains that are part of a multidomain protein are ______

(a) nethier co-regulated nor colocalized

(b) not co-regulated but colocalized

(c) co-regulated and but not colocalized

(d) co-regulated and colocalized

I have been asked this question in my homework.

This interesting question is from The Use of Gene Order & Phylogeny to Predict Protein topic in section Global Approaches for Studying Protein – Protein Interactions of Bioinformatics

Answer 1

Correct answer is (d) co-regulated and colocalized

Easiest explanation: Therefore, members of stable complexes as well as consecutive enzymes may be involved in gene fusions. However elements of signal transduction chains are seldom part of the same gene, for instance, as it is an essential part of their function that they can be regulated and localized independently.