Question

Which of the following is untrue?

(a) Many entries in the Protein DataBank (PDB) are three-dimensional structures of multiple domains

(b) The structures in PDB provide experimental information about interactions between domains at atomic detail

(c) There are comparatively few three-dimensional structures compared to the amount of data available from the lower resolution large-scale experiments

(d) Many entries in the Protein DataBank (PDB) are two-dimensional structures of multiple domains

The question was posed to me during an internship interview.

This intriguing question comes from Structural Analyses of Domain Interactions topic in chapter Global Approaches for Studying Protein – Protein Interactions of Bioinformatics

Answer 1

Correct option is (d) Many entries in the Protein DataBank (PDB) are two-dimensional structures of multiple domains

The best I can explain: Analysis of structures consisting of multiple domains has uncovered some of the principles of domain interactions in three dimensions. This information can therefore be complementary to the experimental data on protein interactions and to the predicted interactions.