Question

The investigation (Aloy and Russel) of domain combinations in multidomain proteins by Bashton and Chothia focuses on two-domain proteins belonging to the Rossmann domain family.

(a) True

(b) False

The question was posed to me in examination.

This interesting question is from Structural Analyses of Domain Interactions in section Global Approaches for Studying Protein – Protein Interactions of Bioinformatics

Answer 1

Correct option is (a) True

For explanation: These proteins generally consist of one Rossmann domain and one catalytic domain. As for the analysis of transient interactions, all the proteins belonging to one family of catalytic domains form the same type of interface to the Rossmann domains.