Question

Which of the given statements is incorrect?

(a) The processes of domain assortment and gene duplication produce families of proteins in organisms

(b) Following speciation, a newly derived genome will inherit the families of ancestor organisms, but will also develop new ones to meet evolutionary challenges

(c) Comparison of each of the proteins encoded by an organism with every protein, an all-against-all comparison, reveals which protein families have been amplified and what rearrangements have occurred as steps in the evolutionary process

(d) When two or more proteins in the proteome share a high degree of similarity they are least likely to be paralogs

This question was addressed to me in examination.

Question is from Comparative Genomics in chapter Collecting & Storing Sequences in Laboratory of Bioinformatics

Answer 1

Right answer is (d) When two or more proteins in the proteome share a high degree of similarity they are least likely to be paralogs

To explain I would say: When two or more proteins in the proteome share a high degree of similarity because they share the same set of domains, they are likely to be paralogs, genes that arose by gene duplication events. Proteins that align over shorter regions share some domains, but also may not share others. Although gene duplication events could have created such variation, other rearrangements may have also occurred, blurring the evolutionary history.