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Annotation is based on finding significant alignment to sequences of known function in database similarity searches.

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Annotation is based on finding significant alignment to sequences of known function in database similarity searches.

(a) True

(b) False

I had been asked this question during an internship interview.

This intriguing question comes from Comparative Genomics topic in portion Collecting & Storing Sequences in Laboratory of Bioinformatics

1 Answer

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Best answer
Right answer is (a) True

Explanation: Accurate annotation of genome sequences is an important first step in genome analysis. Matches of lesser significance provide only a tentative or hypothetical prediction and should be used as a working hypothesis of function.

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