Question

In all-against-all self comparison, A comparison is made in which every protein is used as a query in a similarity search against a database composed of the rest of the proteome, and the significant matches are identified by a low expect value.

(a) True

(b) False

The question was posed to me during a job interview.

This is a very interesting question from Sequence Assembly and Gene Identification topic in division Collecting & Storing Sequences in Laboratory of Bioinformatics

Answer 1

The correct choice is (a) True

The best I can explain: Many proteins comprise different combinations of a common set of domains, proteins that align along most of their lengths (80% identity is a conservative choice). Hence they are chosen to select those that have a conserved domain structure.