Question

Which of the following is correct?

(a) Viral decay is not sensitive to temperature

(b) Virus production is sensitive to temperature

(c) Virus decay is sensitive to temperature

(d) Viral production and decay increase with temperature

I had been asked this question in homework.

My question is taken from Gene Therapy Using Viral Vectors in division Utilizing Genetically Engineered Organisms & Medical Applications of Bioprocess Engineering of Bioprocess Engineering

Answer 1

Correct answer is (c) Virus decay is sensitive to temperature

Best explanation: Both the rate of virus production and viral decay decrease with temperature, the rate of decay is more sensitive to temperature. Thus the amount of potentially active virus is severalfold higher when produced at 28°C. However, the transduction efficiency did not increase, presumably due to changes in proteoglycan concentration.