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Which enzyme removes the positive supercoils generated when the replication fork?

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Which enzyme removes the positive supercoils generated when the replication fork?

(a) helicase

(b) endonuclease

(c) exonuclease

(d) gyrase

The question was asked in a national level competition.

My question is taken from DNA Replication in chapter DNA Replication and Repair, Cellular Reproduction of Cell Biology

1 Answer

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Best answer
Right choice is (d) gyrase

Easiest explanation: DNA gyrase is an enzyme belonging to the topoisomerase-II type of enzymes. The basic function of DNA gyrase is to relieve the mechanical stress and the positive supercoils that build up during replication.

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