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Movement of the replication fork generates ________________ in the unreplicated portion of DNA.

(a) positive supercoils

(b) negative supercoils

(c) untranslated regions

(d) amino acid substitutions

The question was asked in unit test.

This key question is from DNA Replication in division DNA Replication and Repair, Cellular Reproduction of Cell Biology

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Correct answer is (a) positive supercoils

The best I can explain: The replication fork moves bidirectionally starting from the origin of replication and moving in the opposite direction, unwinding the double helix along the way. Positive supercoils are generated in the unreplicated, wound portion of the DNA.

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