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When was the link between enzymes and inherited disease first elucidated?

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When was the link between enzymes and inherited disease first elucidated?

(a) 1708

(b) 1808

(c) 1908

(d) 2008

This question was addressed to me in an international level competition.

This intriguing question originated from Gene Expression topic in chapter Gene Expression of Cell Biology

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The correct choice is (c) 1908

Easiest explanation: Archibald Garrod was a Scottish physician who in 1908 reported that the absence of an enzyme led to an inherited disorder Alcaptonuria.

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