Question

The Cholera toxin produced by Vibrio cholera exerts its effect by _____________________

(a) modifying G-protein

(b) modifying primary messengers

(c) modifying effectors

(d) modifying receptors

This question was posed to me by my school principal while I was bunking the class.

The query is from Cell Signaling and Signal Transduction topic in section Cell Signaling and Signal Transduction of Cell Biology

Answer 1

The correct answer is (a) modifying G-protein

The best explanation: The cholera toxin exerts its effect by inhibiting the GTPase activity of G-proteins in the cells of intestinal epithelium and modifying their G-alpha subunits. This causes the epithelial cells to secrete large volumes of fluid into the intestinal lumen.