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ESE bound to SR proteins ______________ splicing and ESE bound to hnRNA ______________ splicing.

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ESE bound to SR proteins ______________ splicing and ESE bound to hnRNA ______________ splicing.

(a) Activate, activate

(b) Activate, inactivate

(c) Inactivate, activate

(d) Inactivate, inactivate

The question was posed to me in semester exam.

This interesting question is from Post-Transcriptional Modification in section Gene Expression : Transcription Prokaryotes of Cytogenetics

1 Answer

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Correct answer is (b) Activate, inactivate

Easy explanation: Binding of SR proteins to ESE or exon splicing enhancers promotes splicing where that exon is retained. hnRNA is a competitive inhibitor of SR proteins that tend to bind ESE as well, thus it inactivates.

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