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Which antibiotic inhibits peptidyl transfer by blocking the accommodation of aa-tRNA into the peptidyl transferase (A/A) site?

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Which antibiotic inhibits peptidyl transfer by blocking the accommodation of aa-tRNA into the peptidyl transferase (A/A) site?

(a) Chloramphenicol

(b) Penicillin

(c) Tetracyclin

(d) Viomycin

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Question is from Ribosome in portion Gene Expression : Translation of Cytogenetics

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The correct answer is (c) Tetracyclin

Explanation: While chloramphenicol also blocks the peptidyl transferase activity, tetracycline does so by blocking the A site. Then the A site amino acid can’t interact with the P site one for the reaction to take place.

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