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RAP1 binds to ____________

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+1 vote
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in Chemical Reaction Engineering by (679k points)
RAP1 binds to ____________

(a) At the loop between enhancer and promoter

(b) Linear repeated sequences

(c) At the nuclosomes in telomere region

(d) Specific sequences at telomere

I had been asked this question during an interview for a job.

This intriguing question originated from Transcription in Eukaryotes : Gene Silencing at Telomere topic in chapter Gene Expression : Transcription Prokaryotes of Cytogenetics

1 Answer

+2 votes
by (1.6m points)
Right option is (b) Linear repeated sequences

Explanation: RAP1 has no sequence specification. It binds to the repeated sequences at the telomeric region in the linear DNA lacking nucleosomes. Then, it loops over and spreads the repression to the entire telomere.

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