Question

Which of these is not true for TFIIH?

(a) It is a helicase

(b) On initiation the RNA pol starts transcribing leaving TFIIH at pre-IC

(c) It has kinase activity

(d) It is needed in Double Strand Break (DSB) repair

This question was posed to me in exam.

This interesting question is from Transcription in Eukaryotes : Transcription Factors topic in division Gene Expression : Transcription Prokaryotes of Cytogenetics

Answer 1

Correct answer is (b) On initiation the RNA pol starts transcribing leaving TFIIH at pre-IC

To explain: TFIIH is necessary for phosphorylating RNA pol and triggering its initiation. It moves on with the RNA pol after initiation starts. It also acts as a helicase which is put to use during DSB repair.