Question

The DSB are indistinguishable from normal chromosomes of shorter length.

(a) True

(b) False

I have been asked this question in an international level competition.

My query is from Repair of DNA Damage: Recombinational and Bypass in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Answer 1

Correct answer is (b) False

Easiest explanation: DSB is in the endonuclear region. So the ends created lack telomere. DNA ends produced by synthesis in vitro have 5’ tri-phosphate and that in between strands has 5’ monophosphate, DSB can thus be distinguished from normal chromosomal ends.