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Aneuploidy is usually deleterious as _________________

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Aneuploidy is usually deleterious as _________________

(a) Chromosomal pairing is hampered

(b) Gene balance is disrupted

(c) Size of individual may vary

(d) Chromosomal disintegration is increased

I got this question in an internship interview.

My question comes from Chromosomal Abnormalities : Aneuploidy in section Chromosomal Basis of Inheritance of Cytogenetics

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The correct choice is (b) Gene balance is disrupted

The best I can explain: In case of aneuploidy there is loss or gain in single chromosome which results in dis-balance of the genes and their products. This is a reason that aneuploids are usually lethal.

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