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You hybridize two cells one of which carries a deletion mutation on chromosome 1. What will you expect to observe?

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You hybridize two cells one of which carries a deletion mutation on chromosome 1. What will you expect to observe?

(a) Buckling of chromatin of 1^st cell

(b) Buckling of chromatin of 2^nd cell

(c) Twisting and loop formation between the two chromatins

(d) No observable difference

The question was asked in class test.

Question is from Chromosomal Abnormalities : Deletion in division Chromosomal Basis of Inheritance of Cytogenetics

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Right option is (b) Buckling of chromatin of 2^nd cell

Easiest explanation: As chromosome 1 of 1^st cell carries the deletion it will have less genes than that of the counterpart on the 2^nd cell. There will be an error in a pairing where the extra part of 2^nd cell chromatin corresponding to the deleted gene will buckle.

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