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Yellow colour of mouse is generated by _________ mutation.

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Yellow colour of mouse is generated by _________ mutation.

(a) Duplication

(b) Deletion

(c) Inversion

(d) Translocation

This question was posed to me at a job interview.

I want to ask this question from Chromosomal Abnormalities : Deletion in portion Chromosomal Basis of Inheritance of Cytogenetics

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Correct choice is (b) Deletion

For explanation I would say: Here the agouti allele which is to be expressed only in certain tissues is brought under the control of Rally gene promoter which is expressed in all tissues, by deletion of Rally gene and agouti promoter in between the two. The strong promoter over expresses Agouty gene leading to the color.

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