Question

According to the pH-partition hypothesis which one of the given options doesn’t govern the absorption?

(a) The molecular size of the drug

(b) PH at the absorption site

(c) Lipid solubility of unionized drugs

(d) Dissociation constant

This question was addressed to me in an interview for job.

I want to ask this question from Drugs Absorption in division Absorption of Drugs of Drug Biotechnology

Answer 1

Correct choice is (a) The molecular size of the drug

For explanation I would say: The pH-partition hypothesis tells that for drug compounds with molecular weight more than 100, that are transported by passive diffusion across the cell membrane, the process is governed by the capability of lipid solubility of unionized drugs, the dissociation constant of the drug and pH at the absorption site.