Question

What could be the reason that irrespective of pH any drug gets absorbed mostly from the intestine?

(a) More surface area

(b) Long residence time

(c) Large surface area and long residence time

(d) Large surface area, long residence time, basic pH

This question was addressed to me in examination.

Question is from Drugs Absorption topic in portion Absorption of Drugs of Drug Biotechnology

Answer 1

The correct answer is (c) Large surface area and long residence time

The explanation is: Experiments showed that irrespective of the GI pH and the degree of ionization, most of the acidic and basic drugs are more rapidly absorbed from the intestine. The 1st reason because of large surface area and second reason due to high residence time.