Question

Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step.

(a) True

(b) False

This question was addressed to me by my school principal while I was bunking the class.

The above asked question is from Drugs Absorption in section Absorption of Drugs of Drug Biotechnology

Answer 1

The correct option is (b) False

For explanation I would say: Drugs having a large partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step. This applies particularly to high molecular weight fatty acids and bile acids.