Question

Which one of the following sentences depicts the function of Disintegrants correctly?

(a) These agents help in holding the powders together to form granules

(b) These agents overcome the cohesive strength of the tablets and help in dissolution

(c) These agents help in the flow of granules and reduce friction between particles

(d) Added when the required dosage is inadequate

The question was posed to me in an interview for internship.

My doubt stems from Dosage Form Factors Affecting Drug Absorption in section Absorption of Drugs of Drug Biotechnology

Answer 1

The correct choice is (b) These agents overcome the cohesive strength of the tablets and help in dissolution

For explanation I would say: Disintegrants are the agents which overcome the cohesive strength and break them when they come in contact with the water. Binders are the agents that help in holding the powders together to form granules. Lubricants help in the flow of granules and reduce friction between particles. Binders are added when required dosage is inadequate.