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IRE-BP does not bind to _______________

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IRE-BP does not bind to _______________

(a) IRES

(b) Stem loop in 5’ end of Ferritin

(c) Stem loop in 3’ end of Transferrin

(d) AU rich regions in IRE

The question was posed to me in unit test.

This is a very interesting question from Translation in Eukaryotes topic in section Gene Expression : Translation of Cytogenetics

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Correct option is (a) IRES

The best explanation: IRES stands for Internal ribosomal entry site, which in no way is related to iron sensing. The AU rich regions in IRE are actually the step loop in 3’ end of transferring that binds to IRE-BP. Also, the stem loop in 5’ end of ferritin binds IRE-BP.

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