Question

Which of the following will effectively cause normal translation from an initiation AUG, blocked by a strong AUG upstream?

(a) Hairpin loop near the 1^st AUG

(b) No measure required

(c) In frame stop codon between two AUGs

(d) Deletion of the GAP between the two AUGs

I had been asked this question in an online quiz.

Origin of the question is Translation in Eukaryotes in portion Gene Expression : Translation of Cytogenetics

Answer 1

Right option is (c) In frame stop codon between two AUGs

For explanation: If there is in frame stop codon to 1^st AUG there will be an open reading frame in between 1st AUG and stop codon and again another open reading frame from 2^nd AUG. This will lead to effectively normal translation from the 2^nd AUG.