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If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have less amount of drug.

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If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have less amount of drug.

(a) True

(b) False

This question was addressed to me in an interview.

The doubt is from Drugs Absorption topic in division Absorption of Drugs of Drug Biotechnology

1 Answer

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Right choice is (b) False

Easy explanation: If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have more amount of drug. And only the ionized or the undissociated fraction of drug.

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