Question

Which one will be the easiest approach to enhance the solubility and dissolution of any drug?

(a) Micronize the drug

(b) Convert drug into their anhydrous form

(c) Convert drug into their hydrous form

(d) Convert drug into their salt form

This question was posed to me in semester exam.

Question is from Drugs Absorption topic in portion Absorption of Drugs of Drug Biotechnology

Answer 1

The correct option is (d) Convert drug into their salt form

The best I can explain: Most drugs are weak acids or weak base3s. Thus, one of the easiest approaches to enhance the solubility and dissolution of any drug is to convert them into their salt forms.