Question

Which of the following has both kinase and nuclease property?

(a) Pol Beta

(b) Ku-PKC

(c) Ku- pol gamma

(d) Pol delta

This question was posed to me by my college professor while I was bunking the class.

Enquiry is from Repair of DNA Damage: Recombinational and Bypass topic in portion DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Answer 1

Right answer is (b) Ku-PKC

For explanation I would say: Ku PKC has the property of both kinase as well as nuclease. Thus, it can work in non-homologous DSB without the help of additional nucleases.