Question

In an experiment you fuse cells from two patients suffering from XP ( Xeroderma Pigmentosum). The fused cells will be expected to agree to which of the following?

(a) The resultant cells will have worsened case of XP

(b) Only one of the two NER defects that is dominant will be seen

(c) No XP defect in the resultant

(d) Both will show a similar effect of XP as before

I had been asked this question in unit test.

My question comes from Repair of DNA Damage: NER, Direct Reversal topic in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Answer 1

Right option is (c) No XP defect in the resultant

To explain I would say: As the disease Xeroderma pigmentosum is caused by different in different NER gene, such fusion will show complementation and the resultant phenotype will be normal.