Question

Which of the following is not a limitation granulation?

(a) Formation of crystal bridge by the presence of liquid

(b) The liquid may act as a medium for affecting chemical reactions such as hydrolysis

(c) Increase the cost due to more additional processing

(d) The drying step may harm the thermolabile drugs

The question was posed to me in a job interview.

My query is from Dosage Form Factors Affecting Drug Absorption in portion Absorption of Drugs of Drug Biotechnology

Answer 1

Right answer is (c) Increase the cost due to more additional processing

To explain I would say: limitation of wet granulation method is Formation of Crystal Bridge by the presence of liquid, the liquid may act as a medium for affecting chemical reactions such as hydrolysis, and the drying step may harm the thermolabile drugs.