Question

Which of the following is not true about inversion?

(a) Inverted chromosomes are generally viable

(b) Inversion can cause chromosome breakage

(c) Two DNA strands with an inverted segment will not pair

(d) Inversion including centromere is known as paracenric

This question was addressed to me during an internship interview.

This key question is from Chromosomal Abnormality : Inversion topic in chapter Chromosomal Basis of Inheritance of Cytogenetics

Answer 1

The correct option is (c) Two DNA strands with an inverted segment will not pair

Best explanation: Two DNA segments in inversion will pair but the pairing will be via formation of a loop such that appropriate gene loci can come close. Other options about inversion are true.