Question

Which one of the following bonds is not generally a bond through which a drug will bind in our body?

(a) Hydrogen bond

(b) Hydrophobic bond

(c) Ionic bond

(d) Covalent bond

I have been asked this question in an international level competition.

I'm obligated to ask this question of Plasma Protein Drug Binding topic in portion Protein Binding of Drugs of Drug Biotechnology

Answer 1

Right answer is (d) Covalent bond

To explain: Covalent bonds are strong bonds. Drugs always bind through weak chemical bonds such as that of the hydrogen bond, hydrophobic bond, ionic bond, and van der Waal’s forces. These are reversible processes. Irreversible bonding i.e. covalent bonding arises the issue of toxicity or carcinogenicity.