Question

What is the name of the drug binding site I of HSA?

(a) Tamoxifen binding site

(b) Digitoxin binding site

(c) Diazepam binding site

(d) Warfarin and azapropazone binding site

I have been asked this question in an internship interview.

Origin of the question is Plasma Protein Drug Binding topic in division Protein Binding of Drugs of Drug Biotechnology

Answer 1

The correct answer is (d) Warfarin and azapropazone binding site

Easiest explanation: In the structure of HSA there 4 main binding sites for drugs. The site I am called as the warfarin and azapropazone binding site. In this region, a large number of drugs can bind. For example several NSAIDs, phenytoin, sodium valproate, bilirubin.