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Downregulation of caspase 9 is seen in ________________

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Downregulation of caspase 9 is seen in ________________

(a) Melanoma

(b) Breast cancer

(c) Colorectal cancer

(d) Lung cancer

I have been asked this question during an internship interview.

I'm obligated to ask this question of Apoptosis and Cancer topic in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics

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Correct answer is (c) Colorectal cancer

Explanation: Reduced functioning of caspases may prevent apoptosis thus leading to cancer. Down regulation of caspase 12 is seen mostly in case of colorectal cancers.

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